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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Human neural stem cell-derived extracellular vesicles protect against Parkinson’s disease pathologies

Fig. 6

Protective effect of F3-derived EVs on dopaminergic cell viability in 6-OHDA- induced PD mouse model. A Immunofluorescence staining of TH was performed to detect viability of TH-positive dopaminergic neurons in SN. The red box indicates ipsilateral regions. scale bar = 1 mm. B Magnified images of the ipsilateral and contralateral sides of the SN were shown. Degeneration of TH-positive dopaminergic neurons by 6-OHDA was attenuated by F3-derived EVs treatment in SN. N = 3, scale bar = 50 µm. C Schematic diagram for the protective effect of F3-derived EVs against 6-OHDA was shown. Anti-oxidative stress and anti-inflammatory effects of EVs containing miRNAs that are involved in dopaminergic neuronal protection were displayed. NSC neural stem cell. SN substantia nigra, EV extracellular vesicles, ROS reactive oxygen species

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