Microparticles: biogenesis, characteristics and intervention therapy for cancers in preclinical and clinical research

Table 1 Comparisons of EVs

Characteristic	EXOs	MPs	Apoptotic bodies
Origin	Multivesicular bodies	Plasma membrane	Plasma membrane
Size	30–100 nm	100–1000 nm	1000–5000 nm
Density	1.13–1.19 g/cm³	1.04–1.07 g/cm³	1.16–1.28 g/cm³
Sedimentation	≥ 100000 g	10000–20000 g	2000 g and various
Zeta potential	− 16.35 ~ − 11.85 mV	− 30 ~ − 10 mV	/
Appearance	Cup-shaped	Irregular-shaped	Irregular-shaped
Markers	TSG101, tetraspanins and Alix	Integrins, selectins and CD40 ligand	Histones, Annexin V

ISSN: 1477-3155