Table 4 Summary of the application of modified MPs in cancer therapy
Modified MPs | Original cells | Therapeutic agent and incorporation method | Metallic materials and incorporation method | Stress | Isolation method | Cancer type | Image | Refs. |
|---|---|---|---|---|---|---|---|---|
Chemo@UT-MPs | Tumor cell | MTX /Cisplatin/DOX (incubation) | / | UV | Centrifugation | HCC, melanoma ovarian cancer, lung cancer, colon cancer | / | |
YM-155@ DOX@UT-MPs | Tumor cell | DOX and YM-155 (incubation) | / | UV | Centrifugation | Osteosarcoma | / | [134] |
CCION/m-THPC@M-MPs | Macrophage | m-THPC (incubation) | Citrate-coated iron oxide nanoparticles (incubation) | Starvation | Magnetic sorting | Cervical cancer | MRI | [145] |
QDs@VEGF siRNA@E-MPs | Endothelial cell | VEGF-siRNA (electroporation) | DSPE-PEG-biotin SA-QDs (incubation) | Starvation | Centrifugation | Melanoma | NIR | [142] |
DOX@AS1411@E-MPs | Endothelial cell | DOX and AS1411-CHO (incubation) | / | Starvation | Centrifugation | HCC | / | [37] |
Met@Man@UM-MPs | Macrophage | DSPE-PEG-Man and metformin (incubation) | / | UV | Centrifugation | HCC and breast cancer | / | [158] |
OVs@UT-MPs | Tumor cells | Oncolytic adenovirus (infection) | / | UV | Centrifugation | Lung cancer, rectal cancer and ovarian cancer | / | [119] |
Survivin siRNA@QDs@CMPs | Circulating MPs | Survivin siRNA (electroporation) | Ag2Se@Mn QDs/ electroporation | No treatment | Centrifugation | Oral cancer | MRI/NIR | [79] |
DOX@FA/IONP@M-MPs | Macrophage | DOX (electroporation) and DSPE-PEG-FA (incubation) | DSPE-PEG-Biotin and SA-IONPs (incubation) | Starvation | Magnetic sorting | Cervical cancer | / | [153] |
Bcl-2 siRNA/Taxol@FA/biotin@T-MPs | Tumor cell | Bcl-2 siRNA and Taxol (electroporation) DSPE-PEG-FA (incubation) | DSPE-PEG-Biotin and SA-QDs (CdSe/ZnS) (incubation) | Starvation | Centrifugation | Breast cancer | NIR | [155] |
Chemo@UTT-MPs | TRCs | DOX or 5-FU (incubation) | / | UV | Centrifugation | HCC and melanoma | / | [38] |
CpG@Fe3O4@UT-MPs | Tumor cell | CpG@Lipo (incubation) | Nano-Fe3O4 (incubation) | UV | Centrifugation | Melanoma | / | [148] |
TK-NTR@T-MPs | Tumor cell | TK-NTR plasmid (transfection) | / | Starvation | Centrifugation | Breast cancer | / | [99] |
Bi2Se3/DOX@UT-MPs | Tumor cell | DOX (electroporation) | Bi2Se3 (electroporation) | UV | Centrifugation | HCC | CT/PA | [138] |