Fig. 10
Safety evaluation of Fe3O4-siPD-L1@M-BV2 in orthotopic drug-resistant GBM mice. A H&E staining of heart, liver, spleen, lung and kidney tissue in orthotopic drug-resistant GBM mice. B, C Effects of Fe3O4-siPD-L1@M-BV2 on ALT and AST activity in serum of orthotopic drug-resistant GBM mice. D, E Effects of Fe3O4-siPD-L1@M-BV2 on content of BUN and CREA in serum of orthotopic drug-resistant GBM mice. The green area indicates the normal ranges. (n = 5, mean ± SD)