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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Biomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM

Fig. 3

The ferroptosis induced by Fe3O4-siPD-L1@M-BV2 in GL261/TR cells. A Mechanism of ferroptosis. B Effect of Fe3O4-siPD-L1@M-BV2 on the viability of GL261/TR cells. C Effect of Fe3O4-siPD-L1@M-BV2 on the viability of GL261/TR cells in the presence of IFN-γ, Fer-1 and DFO. D Effect of Fe3O4-siPD-L1@M-BV2 on GSH level in GL261/TR cells. E Effect of Fe3O4-siPD-L1@M-BV2 on the protein expression of GPX4 in GL261/TR cells in the presence of Fer-1 and DFO. F Effect of Fe3O4-siPD-L1@M-BV2 on the protein expression of GPX4 in GL261/TR cells in the presence of IFN-γ. G Effect of Fe3O4-siPD-L1@M-BV2 on ROS (marked with DHE, red color) and LPO (marked with BODIPY-C11, green color) level in GL261/TR cells. H Statistic analysis of effect of Fe3O4-siPD-L1@M-BV2 on ROS level in GL261/TR cells. I Statistic analysis of effect of Fe3O4-siPD-L1@M-BV2 on LPO level in GL261/TR cells. J Effect of Fe3O4-siPD-L1@M-BV2 on H2O2 level in GL261/TR cells. (n = 3, mean ± SD, *P < 0.05, **P < 0.01; ns: no significant difference)

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