Fig. 7
The therapeutic effect of Fe3O4-siPD-L1@M-BV2 on orthotopic drug-resistant GBM in mice. A Schematic diagram of drug administration and observation of therapeutic effect. B The inhibitory effect of Fe3O4-siPD-L1@M-BV2 on the growth of orthotopic drug-resistant GBM observed by in vivo bioluminescence imaging. C Statistical analysis of orthotopic drug-resistant GBM growth. (n = 6, mean ± SD, *P < 0.05, **P < 0.01). D Effects of Fe3O4-siPD-L1@M-BV2 on the survival time of orthotopic drug-resistant GBM mice. (n = 10, mean ± SD, *P < 0.05, **P < 0.01). E H&E, Ki67 and TUNEL staining of orthotopic drug-resistant GBM tissue. F Semi-quantitative analysis of Ki67 expressed in orthotopic drug-resistant GBM tissue. (n = 3, mean ± SD, *P < 0.05, **P < 0.01). G Semi-quantitative analysis of TUNEL positive cells in orthotopic drug-resistant GBM tissue. (n = 3, mean ± SD, *P < 0.05, **P < 0.01)