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Fig. 8 | Journal of Nanobiotechnology

Fig. 8

From: Biomimetic GBM-targeted drug delivery system boosting ferroptosis for immunotherapy of orthotopic drug-resistant GBM

Fig. 8

Effect of Fe3O4-siPD-L1@M-BV2 on immune microenvironment and ferroptosis in orthotopic drug-resistant GBM tissue. A The protein expression of PD-L1, xCT and GPX4 in orthotopic drug-resistant GBM tissue detected by western blot. B Statistic analysis of PD-L1, xCT and GPX4 protein expression. C The protein expression of PD-L1, GPX4 and ROS level in orthotopic drug-resistant GBM tissue observed by immunofluorescence staining. D The content of GSH in orthotopic drug-resistant GBM tissue. E Statistic analysis of ROS level in orthotopic drug-resistant GBM tissue. F The ratio of matured DC cell in orthotopic drug-resistant GBM tissue. G, H The proportion of Teff cell and Treg cell in orthotopic drug-resistant GBM tissue. IM The content of TNF-α, IFN-γ, IL-6, IL-10 and IL-12 in orthotopic drug-resistant GBM tissue. (n = 3, mean ± SD, *P < 0.05, **P < 0.01)

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