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Table 1 The demographic and clinicopathologic characteristics of the patients in three cohorts

From: Identification and evaluation of circulating small extracellular vesicle microRNAs as diagnostic biomarkers for patients with indeterminate pulmonary nodules

Characteristic

Training cohort

(n = 47)

Testing cohort

(n = 62)

External cohort

(n = 99)

Categories—no. (%)

 Benign

17 (36.2)

24 (38.7)

20 (20.2)

 Malignant

30 (63.8)

38 (61.3)

79 (79.8)

 Age, mean (SD)

58.7 (12.5)

58.1 (10.7)

57.9 (11.9)

Age, no. (%)

 < 60

24 (51.1)

28 (45.2)

49 (49.5)

 ≥ 60

23 (48.9)

34 (54.8)

50 (50.5)

Gender, no. (%)

 Female

20 (42.6)

37 (59.7)

55 (55.6)

 Male

27 (57.4)

25 (40.3)

44 (44.4)

Smoking status, no. (%)

NA

 Yes

12 (25.5)

6 (9.7)

 

 No

35 (74.5)

56 (90.3)

 

Pathology, no. (%)

 AIS

3 (6.4)

6 (9.7)

10

 MIA

10 (21.3)

11 (17.7)

5

 Invasive

17 (36.2)

21 (33.9)

66

 AAH

2 (4.3)

2 (3.2)

0

 Fibrosis

2 (4.3)

4 (6.5)

0

 Granulomas

4 (8.5)

3 (4.8)

0

 Hamartoma

2 (4.3)

3 (4.8)

3

 OP

4 (8.5)

4 (6.5)

0

 Other benign subtypes

3 (6.4)

8 (12.9)

15

Nodule diameter (cm), no. (%)

 ≤ 1

12 (25.5)

24 (38.7)

21 (21.2)

 > 1

35 (74.5)

38 (61.3)

78 (78.8)

Malignant stages, no. (%)

NA

 0

3 (10.0)

6 (15.8)

 

 IA1

12 (40.0)

13 (34.2)

 

 IA2

5 (16.7)

11 (28.9)

 

 IA3

6 (20.0)

4 (10.5)

 

 IB

1 (3.3)

0

 

 IIA

2 (6.7)

0

 

 IIB

0

1 (2.6)

 

 IIIA

1 (3.3)

3 (7.9)

 
  1. AIS adenocarcinoma in situ, MIA minimally invasive adenocarcinoma, AAH atypical adenomatous hyperplasia, OP organizing pneumonias, NA not available