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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: A multifunctional composite hydrogel as an intrinsic and extrinsic coregulator for enhanced therapeutic efficacy for psoriasis

Fig. 4

Skin permeability and irritation assessments of various formula hydrogels. a Penetration of NR-labeled MTX-ZA (red) through psoriatic skin at 0.5, 2, 6, and 24 h after administration was observed by CLSM. b Photograph and histopathological images of mice back skin in skin irritation study (the green asterisk: confluent nests of apoptotic keratinocytes, the red arrows: perivascular infiltrate of lymphocytes). Scale bars:50 μm, the nuclei were stained with DAPI (blue); KLK7 (green) was dyed to distinguish the SC layer, HF (hair follicles), SC (stratum corneum), VE (visible epidermal), DE (dermis). The white arrows indicate NR-labeled MTX-ZA. Sham: control group, DNCB: 1% 2,4-dinitrochlorobenzene (DNCB)-induced contact dermatitis groups, F3: Car@MTX-ZA hydrogel, N1: Car@NMs@MTX hydrogel, N2: Car@NMs@ZA hydrogel, N3: Car@NMs@MTX-ZA hydrogel

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