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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: A multifunctional composite hydrogel as an intrinsic and extrinsic coregulator for enhanced therapeutic efficacy for psoriasis

Fig. 6

Impediment of IMQ-induced inflammatory circuits caused by Car@NMs@MTX-ZA hydrogel. a, b qRT–PCR and ELISA analysis of innate cytokine profiles in dorsal skin lesions after different treatments (n = 4, mean ± SEM). c Immunofluorescence co-staining of F4/80 (green) and p-p65 (red) in the dorsal skin lesions, scale bars:20 μm. d Skin lesions were stained with K17 (green). Scale bars:20 μm, *p < 0.05, ***p < 0.001, ****p < 0.0001 vs. IMQ group, sham: control group, IMQ: imiquimod group, N1: Car@NMs@MTX hydrogel, N2: Car@NMs@ZA hydrogel, N3: Car@NMs@MTX-ZA hydrogel

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