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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Bacteria-driven hypoxia targeting delivery of chemotherapeutic drug proving outcome of breast cancer

Fig. 2

Characterization of Bif@DOX-NPs (Bifidobacterium infantis and adriamycin nanoparticle-bound hybrids). A CLSM image analysis of the linkage of FITC-labelled Bif and adriamycin nanoparticles prepared from three different nanomaterials (BSA, human serum albumin and keratin). The adriamycin nanoparticles synthesized from the three materials are indicated by BSA-NPs, HSA-NPs, and KER-NPs respectively. The rightmost graph shows the fluorescence co-localization analysis of the three bacterial nanohybrids (Bif@BSA-NPs, Bif@HSA-NPs, Bif@KER-NPs). B In vitro release profile of DOX, DOX-NPs in PBS at pH 7.4 and Bif@DOX-NPs at pH 5.0, 6.0 and 7.4 (n = 3, mean ± SD). C Anaerobic incubation of Bif and Bif@DOX-NPs for 24 h and counting the number of bacteria in (D). Data are presented as mean ± SD (n = 3). (ns: no statistical significance)

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