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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Bacteria-driven hypoxia targeting delivery of chemotherapeutic drug proving outcome of breast cancer

Fig. 3

Cellular uptake and cytotoxicity. A The fluorescence microscopy microscopic images of DOX and DOX-NPs uptake by 4T1 cells. B Flow cytometry analysis of DOX and DOX-NPs uptake by 4T1 cells and C The relative mean fluorescence intensity (MFI) corresponding to flow cytometry analysis. Data are presented as mean ± SD (n = 3, ***P < 0.001). D The cytotoxicity of BSA-NPs on 4T1 cells (n = 6). E The cytotoxicity of DOX, DOX-NPs and Bif@DOX-NPs on 4T1 cells. Data are presented as mean ± SD (n = 3, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). F Flow cytometry analysis of apoptosis rates of liver cells (LO2) and lung cells (BEAS-2B) induced by Bif. Data are presented as mean ± SD (n = 3, ns no statistical significance)

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