Table 1 Common enzymatic mechanisms in MOF-NZs for therapeutic and diagnostic activities

Oxidase

TPZ-GOx-ZIF-8@eM

Tumor therapy by Starvation/CHT in CT26 tumor xenografts model

[48]

Mem@GOx@ZIF-8@DOX

Tumor therapy by Starvation/CHT in 4T1 tumor xenografts model

[49]

PCN@Pt@PCN-Au-FA

Tumor therapy by Starvation/PDT in 4T1 tumor xenografts model

[50]

GOx@ZIF@MPN

Tumor therapy by Starvation/CDT in 4T1 tumor xenografts model

[51]

Co‐Fc@GOx

Tumor therapy by Fenton reaction/CDT in 4T1 tumor xenografts model

[52]

GOx-Hb@ZIF-8

Tumor therapy by Fenton reaction/starvation therapy in MCF-7 and HeLa cancerous cells model

[53]

AuNPs-Fe@GOx

Tumor therapy by PTT in microenvironment tumor model

[54]

Peroxidase

DOX@MIL-100@HA

Tumor therapy by CDT/CHT in MCF-7 tumor xenografts model

[55]

IL@MIL-101(Fe)@ BSA-AuNCs

Tumor therapy by CDT/ PDT therapy in H22 liver tumor xenografts model

[56]

DOX@PCN@-MnO2@PAH

Tumor therapy by glutathione-depletion /CHT/PDT in 4T1 tumor xenografts model

[57]

BPQD/HKUST-1@MIL-100 (Fe)-GSNO

Tumor therapy by CDT/gas therapy/PTT in human gastric tumor xenografts model

[58]

UsAuNPs/MOFs

Antibacterial therapy in antibacterial properties against both Gram‐negative and Gram‐positive bacteria model

[59]

CAT

BQ-MIL@CAT-MIL

Tumor therapy by O₂-evolving/PDT/PTT in human cervical cancer tumor xenografts model

[60]

mZIF-8@-CAT@DOX

Tumor therapy by O₂-evolving/CHT/IMT in mouse melanoma tumor xenografts model

[61]

BM@NCP(DSP)-PEG

Tumor therapy by O₂-evolving/radiotherapy/IMT in 4T1 tumor xenografts model

[62]

MOF-MBDHA@PLA@PEG

Tumor therapy by O₂-evolving/PDT/CHT in mouse cervical tumor xenografts model

[63]

MIL-100/GOx@HA-PDA

Tumor therapy by CDT/PTT/starvation in 4T1 tumor xenografts model

[64]

SOD

PVP@CeNPs@MIL-100

Alzheimer therapy by CDT in AD mouse model

[65]

Aptinib@PCN@MnO2@Tm

Tumor therapy by GSH-depletion/PDT/antiangiogenesis in 4T1 tumor xenografts model

[66]

Pt@PCN222-Mn

Anti-inflammatory by CDT in IBD of mouse model

[67]

Cu-TCPP-MOFs/nanodosts

Anti-inflammatory by hemodynamic therapy in an endotoxemia model in vivo

[68]

PCN-224(Cu)GOx@MnO2

Tumor therapy by GSH-depletion/CHT/anti-angiogenesis in U14 tumor xenografts model

[69]

NH₂- MIL-88B (Fe)

Tumor therapy by GSH-depletion/nano therapy in A375 and HeLa tumor xenografts model

[70]