Skip to main content
Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer

Fig. 2

Schematic diagram of nanoparticle synthesis and intracellular delivery of CEAMB NPs. A Synthesis of CEAMB NPs. Carboxymethyl chitosan (CMC) containing histidine, cholesterol, and EGFR monoclonal antibodies were synthesized into CHCE, and then self-assembled with Adriamycin, MVP-siRNA, and BCL2-siRNA to form CEAMB NPs. B The cell uptake, intracellular transport, and anti-tumor mechanism of CEAMB NPs. The CEAMB NPs have a specific tumor-targeted delivery capability and sensitive pH-responsive protonation capability, enhancing the cellular uptake and the lysosomal escape. The CEAMB NPs can silence the MVP-mRNA and BCL2-mRNA to inhibit drug efflux and anti-apoptosis of tumor cells, enhancing the anti-tumor effect of Adriamycin

Back to article page