Fig. 3

Preparation and characterization of CEAMB NPs. A Schematic diagram of the chemical method for the synthesis of CEAMB NPs. The CHCE was generated and then self-assembled with siRNA and Adriamycin to generate CEAMB NPs. B The images and particle size distribution of CEAMB NPs. Scale bar, 400 nm. Zeta potential distribution C and size distribution D of CEAMB NPs in PBS buffers with different pH. E–G The particle size distribution and morphology of CEAMB NPs in 50% serum at 0, 6, and 12 h. Scale bar, 200 nm. (The full pictures by SEM are shown in Additional file 1: Fig. S4)