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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Multifunctional nanoparticles co-loaded with Adriamycin and MDR-targeting siRNAs for treatment of chemotherapy-resistant esophageal cancer

Fig. 6

Detection of the lysosomal escape of CEAMB NPs in 510K cells (The laser confocal images are shown in Additional file 1: Fig. S6). The CEAMB NPs were incubated with 510 K cells. Next, the colocalization fluorescence intensity distribution and 2.5D images were taken for the colocalization of lysosome and siRNA (A), lysosome and Adriamycin (B), Adriamycin and siRNA (C), respectively. The observed targets were labeled with three colors: Adriamycin is green, siRNA is red, and lyso-tracker is purple. The degree of the colocalization was measured at the indicated time points with groups of lysosome and siRNA (D), lysosome and Adriamycin (E), Adriamycin, and siRNA (F)

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