Fig. 8

The in vivo antitumor activity of different formulations. a The tumor volume and (b) body weight changes in MCF-7 tumor-bearing mice after treatments with 5% glucose and various liposomes carrying siPLK-1 (siN.C.) and DTX. Data are presented as the means ± SD (n = 6–7). *P < 0.05 and ***P < 0.001. Expression of the PLK-1 (c) mRNA and (d) protein in tumors was detected 24 h after the last administration (n = 3). *P < 0.05 and **P < 0.01. e TUNEL- and H&E-stained MCF-7 tumor slices from various groups