Fig. 7

MPSNs@R837-mediated PDT and PTT in vivo: A Schematic of treatment schedule in 4T1 orthotropic mammary tumor model. Mice were randomly divided into 6 groups: (1) saline-only, (2) free R837, (3) MPSNs, (4) MPSNs@R837, (5) MPSNs (+), (6) MPSNs@R837 (+). B In vivo apoptosis and/or necrosis of the tumor induced by different treatment as shown by H&E staining (scale bar = 100 μm) and TUNEL assay (scale bar = 50 μm). C Tumor volume D Tumor weight. E Tumor picture. F and (G) DC maturation in the tumor-draining lymph nodes induced by different treatment on mice. H–J cytokine levels of TNF-α, INF-γ and IL-12 in sera from mice. Data are mean ± SD (n = 5), statistical significances were calculated via Student’s t test, *p < 0.05, **p < 0.01