Fig. 6
From: Structure based innovative approach to analyze aptaprobe–GPC3 complexes in hepatocellular carcinoma
Representative imaging of in vivo monitored the hepatocellular carcinoma (HCC) tumor by GPC3_3 aptaprobe. A In vivo fluorescence imaging of subcutaneous HCC-bearing mice after intravenous injection of ControlCy5.5 and GPC3_3Cy5.5 (Each of 2 mg/kg aptaprobes). The color scales show total fluorescence signal values ranging from 0.4 × 109 (blue) to 5.0 × 109 (red). Tumors are indicated by red circle. B Cy5.5-labeled control and GPC3_3 aptaprobe fluorescence intensity normalized to tumor area for comparison of in vivo labeled HCC xenograft model (P value by Welch’s t-test). C Imaging of ControlCy5.5 and GPC3_3Cy5.5 injected tumor tissue in sacrificed HCC mice with increased fluorescence sensitivity. The color scales show total fluorescence signal values ranging from 0.3 × 109 (red) to 2.5 × 109 (yellow)