Fig. 1From: Carbonic anhydrase IX-targeted H-APBC nanosystem combined with phototherapy facilitates the efficacy of PI3K/mTOR inhibitor and resists HIF-1α-dependent tumor hypoxia adaptationPreparation and characterization of H-APBC. TEM images of a ZIF-8, b ZIF-PDA, c HPDA, d H-APBC. e XRD patterns of ZIF-8, ZIF-PDA and HPDA. f UV–vis–NIR absorption spectra of H-APBC and free components. The energy variation of BEZ235 (g) or Ce6 (h) and PDA before combination and after combination. The DFT calculation was carried out by Gaussian 09 with b3lyp/6-31 g* (PCM) methodBack to article page