Fig. 3
From: Preclinical safety and hepatotoxicity evaluation of biomineralized copper sulfide nanoagents
Body weight and rat livers in the subacute toxicity study by LNPs and SNPs. Rats were subjected to LNPs or SNPs daily for 14 consecutive days followed by a 28-day recovery period. A Body weight growth profiles of the rats from the control group and dosing groups treated with LNPs or SNPs. Rats were IV administered LNPs (L2, L5, L8) and SNPs (S2, S5, S8) at 2, 5, and 8 mg/kg for 14 consecutive days. B Body weight growth profiles of the rats from the control group and recovery groups. Here, rats were subjected to LNPs (L8-R) or SNPs (S8-R) at 8 mg/kg daily for 14 days followed by a 28-day recovery period. C The liver morphology of the rats from the control group (Ctrl), dosing groups (L8 or S8) and recovery groups (L8-R or S8-R)