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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Preclinical safety and hepatotoxicity evaluation of biomineralized copper sulfide nanoagents

Fig. 6

BSA@Cu2−xS NPs accumulation in the liver and cellular uptake study of NPs in isolated hepatic cells. A NPs accumulation in rat livers treated with 8 mg/kg LNPs and SNPs after the dosing and recovery period. B Freshly isolated hepatocytes were incubated with 10 μg/mL LNPs and SNPs for 6 h. C Uptake of LNPs and SNPs in rat primary hepatocyte spheroids at different time points. D Freshly isolated Kupffer cells were incubated with 10 μg/mL LNPs and SNPs for 6 h. Cu content was quantified by ICP-MS. Values are represented as the mean ± SD. Statistical significance was assessed using one-way ANOVA (NS: no significance, *p < 0.05, **p < 0.01)

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