Fig. 7
From: Preclinical safety and hepatotoxicity evaluation of biomineralized copper sulfide nanoagents
The differentially expressed genes (DEGs) and differential KEGG enrichment analysis between the control and LNPs/SNPs dosing groups (L8 and S8). A The Venn diagram showing the number of shared DEGs and differential KEGG pathways in the L8 and S8 groups compared to the control group. B Scatter plot of KEGG enrichment analysis of DEGs between the control and LNPs and SNPs dosing groups (L8 and S8). The top 20 KEGG pathway enrichments with DEGs are listed here. The rich factor (X-axis) indicates the ratio of DEGs enriched in a pathway to the total genes in that pathway. The diameter of the dots represents the absolute number of DEGs, and the color indicates the p value. L8 and S8: Rats were IV administered LNPs and SNPs, respectively, at a dose of 8 mg/kg daily for 14 consecutive days