Table 2 List of various AuNPs-based nanoconstructs under clinical trials
Interventions | Details | No. enrolled/age | Type of cancer | Phase | NCT number | Sponsor/collaborator | Summary |
|---|---|---|---|---|---|---|---|
Aurimune (CYT-6091) | Tumor necrosis factor-bound colloidal AuNPs | 60/18Â years/adult, old adult | Advanced solid tumors | I | NCT00356980 | National Institutes of Health Clinical Center | TNF-bound colloidal gold, may stimulate the immune system in different ways and stop tumor cells from growing |
Tumor necrosis factor-bound colloidal AuNPs | 84/18 years and older | Breast, colon, gastrointestinal, kidney, liver, melanoma, ovarian, pancreatic, sarcoma, adrenocortical | I | NCT00436410 | National Institutes of Health Clinical Center | This clinical trial is studying tumor necrosis factor in patients undergoing surgery for primary cancer or metastatic cancer | |
AureoLase® | Au nano-shells on silica core illumination with an 808 nm laser | 11/18 years to 130 years | Head and neck cancer | Pilot study | NCT00848042 | Nanospectra Biosciences, Inc | The tumor site is externally illuminated with NIR laser to activate the particles, resulting thermal ablation of the tumor |
Silica-gold nanoshells coated with PEG | 1/18 years and older adult | Prostate | Pilot study | NCT01679470 | Nanospectra Biosciences, Inc | Thermal ablation of tumor | |
Au nanoshells | 60/ 45 years and older adult | Prostate | Recruiting | NCT04240639 | Nanospectra Biosciences, Inc | To determine the efficacy of using MRI/US fusion imaging technology to direct focal ablation of prostate tissue using nanoparticle-directed laser irradiation | |
45/45 year and older adult | Prostate | Completed | NCT02680535 | Nanospectra Biosciences, Inc | MRI/US Fusion imaging and biopsy in combination with nanoparticle directed Focal therapy for ablation of prostate tissue | ||
NU-0129 | Spherical Nucleic Acid (SNA)Â AuNPs | 8/18 years and older | Glioblastoma | Phase 1 | NCT03020017 | Northwestern University/National Cancer Institute | Spherical Nucleic Acid AuNPs Targeting BCL2L12, NU-0129 can cross the blood brain barrier and stop cancer cells from growing |