Fig. 4
The Distribution of the MnCO3-ICG Complexes on 4T1 Tumor-bearing Mice. A Time course of blood levels of MnCO3-ICG levels following intravenous injection. B In vivo MRI images and (D) fluorescence images of BALB/C tumor-bearing mice taken at different time points after injection of MnCO3-ICG. C Quantification analysis of MRI signal change in tumor/muscle based on region of interest (ROI) analysis on images from panel B. E Quantification analysis of the tumor ratio of fluorescence signal change in tumors based on ROI from panel D. F Biodistribution of Mn (% injected dose (ID) Mn per gram tissue) in main tissues and tumors after intravenous administration of MnCO3-ICG. G Thermal images and (H) real-time temperature curve of BALB/C tumor-bearing mice treated with MnCO3-ICG and 808 nm laser (0.5 W/cm2) irradiation