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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Intracellular marriage of bicarbonate and Mn ions as “immune ion reactors” to regulate redox homeostasis and enhanced antitumor immune responses

Fig. 5

In vivo therapeutic efficacy and immunity response of the MnCO3-ICG complexes on 4T1 Tumor-bearing Mice. A Therapy approach for tumor-bearing mice. B Tumor growth curves of BALB/C tumor-bearing mice after various treatments (n = 5) (**p < 0.01; ***p < 0.001). C Final tumor weights of BALB/C tumor-bearing mice exposed to different formulations after the different treatment (*p < 0.05; **p < 0.01; ***p < 0.001). D Hematoxylin & eosin (H&E)-stained tumor sections from BALB/C tumor-bearing mice after various treatments (scale bar, 100 μm). E The T2-MR imaging and digital photos of mice through the treatment period (group 5 and group 6). F IL-6, IL-1α and TNF-α in serum obtained from immunized mice. Flow cytometric analyses of the populations of (G) matured DC cells and (H) CD8 + T cells and CD3 + T cells in splenocytes of mice immunized after the different treatment

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