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Fig. 4 | Journal of Nanobiotechnology

Fig. 4

From: Metal ions/nucleotide coordinated nanoparticles comprehensively suppress tumor by synergizing ferroptosis with energy metabolism interference

Fig. 4

Ferroptosis caused by FeGPNPs in CT26 cells. a Effect of FeGPNPs on mitochondrial membrane potential. Scale bar: 20 μm. b CLSM images of Liperfluo staining. Scale bar: 10 µm. c Western blotting of GPX4, NRF2, Keap1, and P62 protein expression in FeGPNP-treated CT26 cells. d Effect of ferrostain-1 on cytotoxicity of FeGPNPs. e Effect of liproxstain-1 on cytotoxicity of FeGPNPs. f Cleaved caspase 3 expression levels in FeGPNP-treated CT26 cells, as determined by Western blot. g Schematic of FeGPNP-induced cell ferroptosis

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