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Fig. 5 | Journal of Nanobiotechnology

Fig. 5

From: Metal ions/nucleotide coordinated nanoparticles comprehensively suppress tumor by synergizing ferroptosis with energy metabolism interference

Fig. 5

In vivo tumor therapy using FeGPNPs in CT26-xenografted mice. a Schematic of experiment design. b Semi-quantitative analysis of ex vivo fluorescence images in major organs at different time points post i.v. injection of FeGPNPs. Inset: Ex vivo fluorescence images of major organs and tumor dissected from CT26 tumor-bearing mice taken at 12 h post i.v. injection of FeGPNPs. c Blood circulation curve of intravenously injected Ce6 labelled FeGPNPs (Ce6- FeGPNPs). Data are means ± SD (n = 3). d Changes of tumor size during therapy. e Digital images of tumors from CT26-bearing mice after 15 days of different treatments. f Average tumor mass excised from CT26-bearing mice after different treatments. g H&E (Scale bar: 100 μm) and TUNEL (Scale bar: 50 μm) staining of tumor sections from tumor-bearing mice. Group I: PBS-treated; Group II: FeGPNP-treated (i.g.); Group III: FeGPNP-treated (i.v.)

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