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Fig. 7 | Journal of Nanobiotechnology

Fig. 7

From: miR-124-3p delivered by exosomes from heme oxygenase-1 modified bone marrow mesenchymal stem cells inhibits ferroptosis to attenuate ischemia–reperfusion injury in steatotic grafts

Fig. 7

HM-exo-targeted inhibition of STEAP3 attenuates ferroptosis in steatotic grafts. A Rats were treated with PBS, M-exos, and HM-exos after LT, and the GSH levels of the liver tissues in each group were measured on POD3. B, C Protein levels of GPX4 in each group. D Immunohistochemistry showing the level of GPX4 in each group. E Fe2+ and relative expression of Ptgs2 mRNA (F) in each group. G Immunohistochemistry showing the level of 4-HNE in each group. H The ultrastructure of the mitochondria in rat hepatocytes was observed using transmission electron microscopy, and the white arrows indicate the damaged mitochondria. I Relative expression of miR-124-3p in the liver tissues of each group, with U6 as the internal reference. J–L Protein levels of STEAP3 and DMT1 in liver tissues of each group. M Immunohistochemistry showing the level of STEAP3 in each group. N, O GSEA analysis of DEGs in the PBS and HM-exo groups. P MPO staining showing the infiltrated neutrophils in liver tissue of each group. Q Relative expression of Il1, Il6, and Tnfa mRNA in liver tissue of each group (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001. LT: Liver transplantation

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Journal of Nanobiotechnology

ISSN: 1477-3155

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