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Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway

Fig. 1

NOX4 blockade suppressed RANKL-induced osteoclastogenesis. A Protein levels of NOX4 during RANKL-induced osteoclastogenesis. B Representative TRAP staining images and quantification of TRAP-positive cells (≥ 3 nuclei) transfected with siNOX4 (C) and treated with GKT. Scale bars, 100 µm. D The expression of osteoclast-specific genes (E) and osteoclast-specific proteins. F Representative fluorescence images of F-actin rings after transfection with siNOX4 (G) and treatment with GKT. Scale bars, 50 µm. H Scanning electron microscopy (SEM) images of the bone resorption area after siRNA silencing (I) and after GKT treatment. Scale bars, 200 µm. ns: no significance, *p < 0.05, **p < 0.01

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