Fig. 3From: NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathwaySilencing Nrf2 reversed the impaired RANKL-induced ROS production. A Representative images of RANKL-induced ROS generation in the RAW264.7 cells transfected with both siNrf2 and siNOX4 (B) or transfected with siNrf2 and pretreated with 50 μM GKT137831. Scale bars, 50 µm. C The gene levels of Nrf2, HO-1, and NQ-O1. D The protein levels of Nrf2, HO-1, and SOD2. *p < 0.05, **p < 0.01Back to article page