Fig. 8

Immunomodulation of macrophages and NETs and tissue regeneration in vivo. a Immunofluorescence staining of CD86 (red, M1 macrophage surface marker) and CD206 (green, M2 macrophage surface marker) on days 1, 3, 7, and 14. (Scale bar: 50 μm). b Immunofluorescence staining of the markers of NETs formation, CitH3(red) and MPO (green), on days 1, 3, 7, and 14 (Scale bar: 50 μm). c CD31 and d α-SMA immunohistochemical staining images of the number of CD31-positive and α-SMA -positive cells in the skin tissues of diabetic mice wounds in different treatment groups (Scale bar: 50 μm)