Skip to main content
Fig. 1 | Journal of Nanobiotechnology

Fig. 1

From: Brain-targeted heptapeptide-loaded exosomes attenuated ischemia–reperfusion injury by promoting the transfer of healthy mitochondria from astrocytes to neurons

Fig. 1

The primary hypothesis of this study. We fabricated brain-targeted multifunctional biomimetic heptapeptide loaded exosomes for the treatment of IS. Heptapeptide loaded macrophage derived exosomes (EXO-Hep) targeted brain and inhibited Drp1/Fis1 interaction to improve the mitochondrial function of astrocyts. As a result, more healthy astrocytic mitochondria were secreted from astrocytes and transferred into neurons for reducing mitochondria-mediated damage of neurons. Finally, EXO-Hep ameliorated IS injury by reducing infarct area and improving neurological performance in tMCAO rats

Back to article page