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Fig. 3 | Journal of Nanobiotechnology

Fig. 3

From: Brain-targeted heptapeptide-loaded exosomes attenuated ischemia–reperfusion injury by promoting the transfer of healthy mitochondria from astrocytes to neurons

Fig. 3

EXO enhanced the accumulation of Hep in the ischemic region in vivo and in vitro. A Confocal images of A1 astrocytes after incubating with EXO and EXO-Hep. Nucleus was stained with Hoechst 33,342 (blue) for 15 min at 37 °C, and both of EXO and EXO-Hep were labelled by PKH26 (red). The scale bar is 50 μm. B Representative fluorescence images of brains of tMCAO rats treated with PBS, free PKH26 and PKH26 labeled EXO-Hep via intravenous injection. C Representative fluorescent images of Co-location of PKH26 labelled EXO-Hep (red) with A1 astrocytes (green) at ischemic area of brains from rats receiving 2 h of intravenous administration of PHK26 labelled EXO-Hep. A1 type astrocytes were stained with anti-C3 (green). The scale bar is 50 μm

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