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Fig. 2 | Journal of Nanobiotechnology

Fig. 2

From: Nectin-4-targeted immunoSPECT/CT imaging and photothermal therapy of triple-negative breast cancer

Fig. 2

99mTc-HYNIC-mAbNectin-4 has high Nectin-4-targeting in vitro and in vivo. a Cellular uptake assays of 99mTc-HYNIC-mAbNectin-4 at 1−8 h (n = 4), ***p < 0.001. b 99mTc-HYNIC-mAbNectin-4 SPECT/CT imaging of xenograft tumor-bearing mice at different time points, each subgraph includes MIP (upper) and transaxial (lower) image. c The H&E and Nectin-4 immunohistochemistry staining results of xenograft tumor tissues, scale bar = 100 μm. d Biodistribution of 99mTc-HYNIC-mAbNectin-4 in different organs and tumors of tumor-bearing mice at 36 h p.i.. ***p < 0.001 (n = 3). e The corresponding T/M and T/B ratio from biodistribution, *p < 0.05, ** < 0.01, ***p < 0.001

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