Fig. 5
From: Nectin-4-targeted immunoSPECT/CT imaging and photothermal therapy of triple-negative breast cancer
The mAbNectin-4-ICG has excellent tumor-specific targeting and retention in Nectin-4-overexpression tumor in vivo. a FL imaging for MDA-MB-468 xenografts tumor-bearing mice administrated with mAbNectin-4-ICG, free ICG or saline. Red circles indicates the tumor sites and green circles indicates the normal muscles (n = 3). b Ex vivo FL imaging for isolated organs/tumors at 48 h p.i. c Semi-quantitative assays of FL signal intensity for b, ****p < 0.0001 (n = 3)