Fig. 4

Targeted distribution of CsA@PPTK in ex vivo and in vivo. A Fluorescence of Cy7.5@PTK (red) or Cy7.5@PPTK (red) on normal and denuded aorta detected by fluorescent microscopic. Endothelium was marked with CD31, which presents green color. Cell nucleus was marked with DAPI, which presents blue color. B Statistical results of Cy7.5 fluorescence intensity in normal and denuded aorta. C Distribution of Cy7.5@PPTK in the hearts of sham and MI/RI mice at 24 h after administration. D The distribution of Cy7.5@PPTK in the heart slice of sham and MI/RI mice at 24 h after administration. n = 3, mean ± SD