Fig. 6

Effect of CsA@PPTK on immune microenvironment of myocardial tissue. A Representative images of CD86 staining (green) and CD206 staining (red) in myocardial tissue of MI/RI mice at 4 days after reperfusion. B The statistical results of fluorescence intensity of CD86/CD206. C IL-1β concentration in heart tissue of MI/RI mice at 4 days after reperfusion. D TGF-β concentration in heart tissue of MI/RI mice at 4 days after reperfusion. E Representative flow cytometer image of regulatory T cells (Tregs; CD4⁺CD25⁺FoxP3⁺) in heart tissue of MI/RI mice at 4 days after reperfusion. F Quantitative data of Tregs in heart tissue of MI/RI mice at 4 days after reperfusion. n = 3, mean ± SD; ^**p < 0.01, ^***p < 0.001 compared with sham group; ^#p < 0.05, ^##p < 0.01, compared with normal saline group