Fig. 10

Schematic design and in vivo therapeutic effect of MNET before (C-F) or after (G-I) thrombolysis. A Preparation of MNET; B Principle scheme of MNET salvaging within an acute IS through the integration of free radical scavenging and natural oxygen sponge influence. C Timeline and design of animal experiments, NET and MNET were injected after 0.5 h post-MCAO surgery. D Neurological tests of MCAO rats received different treatments (n = 6). E Representative photographs of TTC-stained coronal brain slides and F quantitative analysis of infarct volume (n = 6). White areas in the ipsilateral hemisphere represent the infarcted regions. G Timeline and design of animal experiments, NET and MNET were injected after 0.5 h post-MCAO surgery. H Neurological tests of MCAO rats received different treatments (n = 6). I Representative photographs of TTC-stained coronal brain slides and J quantitative analysis of infarct volume (n = 6); White areas in the ipsilateral hemisphere represent the infarcted regions. Reproduced with permission from [181]. Copyright 2020, American Chemical Society