Fig. 3

In vivo CT imaging of exosomes after acute striatal stroke in a mouse model. a–f Ischemic brain: coronal and sagittal three-dimensional (3D) volume rendering views of typical brain, wherein ischemic insult was induced in the striatum in the right hemisphere: a, d 1 h, b, e 3 h, and c, f 24 h post-exosome administration (the ischemic region is demarcated in yellow circle). Exosomes can be seen to migrate and accumulate at the ischemic region at 3 h. g–i Control brain: sagittal 3D volume rendering views of control mouse brain: g 1 h, h 3 h, and i 24 h post-exosome administration. Exosomes penetrated the brain but did not specifically accumulate in any region and were cleared from the brain over 24 h post-administration. Reproduced with permission from [81]. Copyright 2017, American Chemical Society