Fig. 13

Drug release-dependent biodistribution of NMs. A release mechanism of CPT from activatable prodrug by treatment with GSH. In vivo imaging of tumor-bearing mice at different times (0.15, 1, 2, 6, and 24 h) after i.v. injection of: B DCM-C-CPT (0.08 mg/ kg) and DCM-S-CPT (0.08 mg/kg). C fluorescence images of the internal organs after anatomy for DCM-C-CPT and DCM-S-CPT. Reproduced with permission from [30]. Copyright 2014, American Chemical Society