Fig. 14

Drug release-dependent intratumoral accumulation of NMs. Schematic representation of: A ICG/DOX@Gel-CuS NMs fabrication, B mechanism of enzyme-activated DOX release followed by real-time monitoring and quantification by fluorescence/PA dual-modal imaging. C in vivo MSOT images of mice administered ICG/DOX@Gel-CuS NMs at various time points p.i. D in vivo NIR fluorescence images of mice administered NMs via both subcutaneous (dotted arrow) and intratumor (solid arrow) injection at various time points p.i. E NIR fluorescence images of mice administered ICG/DOX@ Gel-CuS NMs through i.v. injection at various time points p.i. F 3D-reconstruction of transillumination fluorescence images of mice administered NMs through i.v. injection at various tilt angles. Reproduced with permission from [233]. Copyright 2018, American Chemical Society