Fig. 4
From: Bioimaging guided pharmaceutical evaluations of nanomedicines for clinical translations
Size-dependent biodistribution of NMs. A activation of Al2O3 NPs by proton irradiation through the 16O(p,α)13 N nuclear reaction. Metal oxide NPs are activated with protons that convert 16O atoms to 13 N atoms by collision. B-E) PET visualization of 13 N-labeled Al2O3 NPs signal at t60: NS10nmNPs B, NS40nmNPs C, NS150nmNPs D, and NS10µmNPs E. F particle size-dependent organ accumulation. G distribution of particle size evaluated by TEM (NS10nm,NS40nm,NS150nm) or DLS (NS10µm). Reproduced with permission from [153]. Copyright 2013, American Chemical Society