Fig. 8

Shape-dependent biodistribution of NMs. Biodistribution of filomicelles in A549 tumor xenograft mice: A upper panel: whole body bioluminescent images of luciferase-transfected A549 tumor xenograft mice (inset: photograph of tumor); lower panel NIR fluorescence image of A549 tumor xenograft mouse that shows the diffuse fluorescence of NIRF-labeled filomicelles in circulation. Transport and distribution in tumors in vivo for nanospheres versus nanorods of the same hydrodynamic diameter. B schematic illustration of nanospheres and nanorods. C Transvascular transport rates and D distribution in orthotopic E0771 mammary tumors in vivo for nanospheres versus nanorods of the same hydrodynamic diameter (33–35 nm); E NPs penetration in tumors. Co-registered in vivo luminescence and X-ray images of the tumor-bearing mice at 1 h (left panel) and 24 h (right panel) p.i. of the various types of ¹⁹⁸Au-incorporated nanostructures: F nanospheres, G nanodisks, H nanorods, and I cubic nanocages. Reproduced with permission from [179, 181, 182]. Copyright 2009, 2014, American Chemical Society; 2011, Wiley-VCH