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Table 1 IC50 values for C44-Fc inhibition of ANGPTL3-induced LPL suppression

From: A novel nanobody-heavy chain antibody against Angiopoietin-like protein 3 reduces plasma lipids and relieves nonalcoholic fatty liver disease

Parameter

Protein

hANGPTL3 (S17-K170)

hANGPTL3 (S17-E460)

mANGPTL3 (S17-T206)

mANGPTL3 (S17-T455)

C44-Fc, IC50 (nM)

1.6

4.6

3.6

5.4

Evinacumab, IC50 (nM)

1.7

5.4

1.8

3.7

Control Ab, IC50 (nM)

NB

NB

NB

NB

  1. The IC50 values were measured using constant concentrations of ANGPTL3 proteins that were less than 2.5-fold of the EC50 values for ANGPTL3-induced suppression of LPL