Fig. 3
The releasing efficiency of L-arginine and safety of PCM-MSN@LA. L-arginine released from PCM-MSN@LA with or without LIFU irradiation (1.0 W/cm2) in HEPES with a PH 7.00–7.30 and b PH 7.35–7.45. c Viability of cardiomyocytes 24 h after incubation with different concentrations of PCM-MSN@LA. d Photographs of RBCs incubated with PCM-MSN@LA particles at different concentrations ranging from 25 to 3200 mg mL−1 for 3 h. The first tube and second tube were representatives of positive and negative hemolysis control respectively. e HE stained images of the lung, liver, spleen, kidney, and heart before and 24 h after administration of 50 mg kg−1 PCM-MSN@LA (scale bar = 50 μm)