Fig. 8From: Heart-targeted amelioration of sepsis-induced myocardial dysfunction by microenvironment responsive nitric oxide nanogenerators in situMyocardium-targeted NO release significantly attenuated LPS-induced apoptosis and decreased the expression of caspase 3 in cardiac tissue. a Representative TUNEL staining of cardiac sections from mice with different treatments. DAPI (blue; nuclei); TUNEL positive (brown; black arrow) (scale bar = 100 μm). b Quantitative analysis of apoptotic cells (n = 8). Data were presented as mean ± SD, *P < 0.05; **P < 0.01. c, d The expression and quantitative analysis of caspase 3 protein (n = 8). Data were presented as mean ± SD. *P < 0.05; **P < 0.01. e Survival analysis of mice with severe sepsis and different treatments (n = 6). aP < 0.05 vs. CLP; bP < 0.05 vs. PCM-MSN@LABack to article page