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Fig. 6 | Journal of Nanobiotechnology

Fig. 6

From: Cavitation assisted endoplasmic reticulum targeted sonodynamic droplets to enhanced anti-PD-L1 immunotherapy in pancreatic cancer

Fig. 6

In vivo SDT for promoting DC maturation and stimulating the expression of proinflammatory cytokines. A Schematic illustration of SDT therapy to enhance DC maturation in orthotopic tumor models; We administrate NDs at Day0, first US at 5 min post injection for enhanced drug accumulation and second US at 6 h post-injection for sonodynamic effect. B DC maturation in the tumor-draining lymph nodes induced by SDT on mice bearing PanC02 tumors, as assessed by flow cytometry after staining with CD11c, CD80, CD86 and live dead and the quantitative data was displayed in (D); Pro-inflammatory cytokine levels of IL-6 (E) and TNF-α (F) in serum from mice were measured at Day 3 after SDT treatment

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