Fig. 4

Evaluation of neurobehavioral recovery and brain atrophy volume of ischemic stroke mice. A The experimental scheme. B Modified neurological severity score (mNSS) of mice that treated with 10% sucrose, FE, PLGA, PLGA-FE, PLT@PLGA, PLT@PLGA-FE, RGD-PLT@PLGA and RGD-PLT@PLGA-FE. n = 14, 7, 7, 7, 6, 11, 11, 11 (from left to right). C Elevated body swing test of mice that treated with 10% sucrose, FE, PLGA, PLGA-FE, PLT@PLGA, PLT@PLGA-FE, RGD-PLT@PLGA, RGD-PLT@PLGA-FE. n = 14, 7, 7, 6, 6, 11, 10, 11 (from left to right). D Grid walking test of mice that treated with 10% sucrose, FE, PLGA, PLGA-FE, PLT@PLGA, PLT@PLGA-FE, RGD-PLT@PLGA, RGD-PLT@PLGA-FE. n = 10, 7, 7, 7, 6, 9, 8, 10 (from left to right). E Hanging wire test of mice that treated with 10% sucrose, FE, PLGA, PLGA-FE, PLT@PLGA, PLT@PLGA-FE, RGD-PLT@PLGA, RGD-PLT@PLGA-FE. n = 14, 7, 7, 7, 6, 11, 9, 11 (from left to right). F Representative cresyl violet-stained brain sections that treated with 10% sucrose, FE, PLGA, PLGA-FE, PLT@PLGA, PLT@PLGA-FE, RGD-PLT@PLGA, RGD-PLT@PLGA-FE at 14 days after stroke. G Quantitative analysis of the ratio of ipsilateral/contralateral hemisphere volume that treated with 10% sucrose, FE, PLGA, PLGA-FE, PLT@PLGA, PLT@PLGA-FE, RGD-PLT@PLGA, RGD-PLT@PLGA-FE. n = 6, 6, 7, 6, 6, 6, 6, 6 (from left to right). Data presented as mean ± SD. *, p < 0.05, **, p < 0.01, ***, p < 0.001