Fig.4
From: Ultrasound-assisted brain delivery of nanomedicines for brain tumor therapy: advance and prospect
A FUS combined with PFCNDs induced BBB opening with acoustic pressure of 0.5 MPa, 1.0 MPa and 1.5 MPa. a–c EB staining of brain; d–g enlarged (× 40) corresponding black rectangle region in H&E stain; g–i enlarged (× 200) corresponding black rectangle region in H&E stain. B Distribution pattern of EB extravasation when nanodroplets or MBs was used as mediating agent combined with FUS [45]